Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii.
نویسندگان
چکیده
Synergy between colistin and the signal peptidase inhibitor MD3 was tested against isogenic mutants and clinical pairs of Acinetobacter baumannii isolates. Checkerboard assays and growth curves showed synergy against both colistin-susceptible strains (fractional inhibitory concentration index [FICindex] = 0.13 to 0.24) and colistin-resistant strains with mutations in pmrB and phosphoethanolamine modification of lipid A (FICindex = 0.14 to 0.25) but not against colistin-resistant Δlpx strains with loss of lipopolysaccharide (FICindex = 0.75 to 1). A colistin/MD3 combination would need to be targeted to strains with specific colistin resistance mechanisms.
منابع مشابه
Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
OBJECTIVE To test the activity of a small molecule compound that targets Lipid II against Acinetobacter baumannii. METHODS Susceptibility to small molecule Lipid II inhibitor BAS00127538 was assessed using carbapenem- and colistin-resistant clinical isolates of A. baumannii. In addition, synergy between colisitin and this compound was assessed. RESULTS Small molecule Lipid II inhibitor BAS0...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 60 7 شماره
صفحات -
تاریخ انتشار 2016